WASET
	@article{(Open Science Index):https://publications.waset.org/pdf/9997725,
	  title     = {Extended Release System of Hypoglycemic Agent Containing Solid Dispersions: Strategies and Mechanisms},
	  author    = {Amit Kumar and  Ramendeep Grawal and  Peeyush Sharma and  Dinesh Puri and  Anil Bhandari},
	  country	= {},
	  institution	= {},
	  abstract     = {The main perspective of the present study aims at overcoming solubility problems by using the technique of solid dispersion. Repaglinide is a BCS Class II drug, having low aqueous solubility and therefore, low bioavailability. Solid dispersions of repaglinide with different carriers Polyvinyl Pyrrolidone (PVP) and Ethyl Cellulose (EC) in different ratios were prepared by suspending method and Dissolving methods. In vitro release studies revealed that the F7 formulation showed extended drug release. So, the dissolution profile of solid dispersion containing EC and PVP K30 (1: 3) was selected as the best formulation because of its extended drug release among all formulations. In conclusion, solid dispersions of Repaglinide in PVP have shown to be a promising approach to improve the bioavailability of Repaglinide.
},
	    journal   = {International Journal of Pharmacological and Pharmaceutical Sciences},
	  volume    = {8},
	  number    = {3},
	  year      = {2014},
	  pages     = {162 - 166},
	  ee        = {https://publications.waset.org/pdf/9997725},
	  url   	= {https://publications.waset.org/vol/87},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 87, 2014},
	}