@article{(Open Science Index):https://publications.waset.org/pdf/9996838,
	  title     = {New Drug Delivery System for Cancer Therapy},
	  author    = {Emma R. Arakelova and  Stepan G. Grigoryan and  Ashot M. Khachatryan and  Karapet E. Avjyan and  Lilia M. Savchenko and  Flora G. Arsenyan},
	  country	= {},
	  institution	= {},
	  abstract     = {The paper presents a new drugs delivery system, based on the thin film technology. As a model antitumor drug, highly toxic doxorubicin is chosen. The system is based on the technology of obtaining zinc oxide composite of doxorubicin by deposition of nanosize ZnO films on the surface of doxorubicin coating on glass substrate using DC magnetron sputtering of zinc targets in Ar:O2 medium at room temperature. For doxorubicin zinc oxide compositions in the form of coatings and gels with 180-200nm thick ZnO films, higher (by a factor 2) in vivo (ascitic Ehrlich's carcinoma) antitumor activity is observed at low doses of doxorubicin in comparison with that of the initial preparation at therapeutic doses. The vector character of the doxorubicin zinc oxide composite transport to tumor tissues ensures the increase in antitumor activity as well as decrease of toxicity in comparison with the initial drug.
},
	    journal   = {International Journal of Pharmacological and Pharmaceutical Sciences},
	  volume    = {7},
	  number    = {12},
	  year      = {2013},
	  pages     = {927 - 932},
	  ee        = {https://publications.waset.org/pdf/9996838},
	  url   	= {https://publications.waset.org/vol/84},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 84, 2013},
	}