TY - JFULL AU - Xiao-Li Dong and Quan-Gui Gao and Sa-Sa Gu and Hao-Tian Feng and Man-Sau Wong and Liya Denney PY - 2012/10/ TI - Long-Term Treatment of Puerariae Radix Extract Ameliorated Hyperparathyroidism Induced by Ovariectomy in Mature Female Rats T2 - International Journal of Bioengineering and Life Sciences SP - 825 EP - 830 VL - 6 SN - 1307-6892 UR - https://publications.waset.org/pdf/9714 PU - World Academy of Science, Engineering and Technology NX - Open Science Index 69, 2012 N2 - Postmenopausal osteoporosis is a disorder characterized by the progressive bone loss induced by estrogen deficiency in postmenopausal women. This imbalance affects calcium–phosphate metabolism and results in secondary hyperparathyroidism. Purariae Radix (PR), the root of P. lobata (Wild.) Ohwi, is one of the earliest medicinal herbs employed in ancient China. PR contains a high quantity of isoflavones and their glycosides, which are regarded as phytoestrogen. Few investigations of PR are related to its osteoprotective effects. The present study is designed to administer PR water extract to ovariectomized (OVX) female rats, for the investigation of its possibly protective actions on bone and to delineate the potential mechanisms involved. Our results demonstrated that long-term treatment of PR could not significantly improve bone properties, whereas it greatly ameliorated the condition of secondary hyperparathyroidism induced by ovariectomy in those animals. PR might be useful as alternative regimen for protecting against postmenopausal bone loss. ER -