@article{(Open Science Index):https://publications.waset.org/pdf/9196,
	  title     = {Design of Salbutamol Sulphate Gastroretentive Nanoparticles via Surface Charge Manipulation},
	  author    = {Diky Mudhakir and  M. Fauzi Bostanudin and  Fiki Firmawan and  Rachmat Mauludin},
	  country	= {},
	  institution	= {},
	  abstract     = {In the present study, development of salbutamol
sulphate nanoparticles that adhere to gastric mucus was investigated.
Salbutamol sulphate has low bioavailability due to short transit time in
gastric. It also has a positive surface charge that provides hurdles to be
encapsulated by the positively strong mucoadhesive polymer of
chitosan. To overcome the difficulties, the surface charge of active
ingredient was modified using several nonionic and anionic
stomach-specific polymers. The nanoparticles were prepared using
ionotropic gelation technique. The evaluation involved determination
of particle size, zeta potential, entrapment efficiency, in vitro drug
release and in vitro mucoadhesion test. Results exhibited that the use
of anionic alginate polymer was more satisfactory than that of
nonionic polymer. Characteristics of the particles was nano-size, high
encapsulation efficiency, fulfilled the drug release requirements and
adhesive towards stomach for around 11 hours. This result shows that
the salbutamol sulphate nanoparticles can be utilized for improvement
its delivery.},
	    journal   = {International Journal of Pharmacological and Pharmaceutical Sciences},
	  volume    = {6},
	  number    = {12},
	  year      = {2012},
	  pages     = {622 - 628},
	  ee        = {https://publications.waset.org/pdf/9196},
	  url   	= {https://publications.waset.org/vol/72},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 72, 2012},
	}