@article{(Open Science Index):https://publications.waset.org/pdf/9024,
	  title     = {Association of G-174C Polymorphism of the Interleukin-6 Gene Promoter with Obesity in Iranian Population},
	  author    = {Rostami F and  Haj Hosseini R and  Sharifi K and  Daneshpour M and  Azizi F and  Hedayati M},
	  country	= {},
	  institution	= {},
	  abstract     = {Expression and secretion of inflammation markers are
disturbed in obesity. Interleukin-6 reduces body fat mass. The
common G-174C polymorphism in the promoter of IL-6 gene has
been reported that effects on transcriptional regulation. The objective
was to investigate association of the common polymorphism G-174C
with obesity in Iranian population. The present study is cross
sectional association study that included 242 individuals (110 men
and 132 women). Serum IL-6 levels, C-reactive protein, fasting
blood glucose and blood lipids profile were measured .BMI and
WHR were calculated. Genotyping is carried out by PCR and RFLP.
The frequencies of G and C allele were 64.5% and 35.5%,
respectively. The G-174C polymorphism was not associated with
BMI and WHR. However in obese individual, fasting blood glucose
was significantly higher in carrier of C allele compared with the noncarrier.
The IL-6 G-174C polymorphism is not a risk factor for
obesity in Iranian population.},
	    journal   = {International Journal of Medical and Health Sciences},
	  volume    = {4},
	  number    = {9},
	  year      = {2010},
	  pages     = {400 - 403},
	  ee        = {https://publications.waset.org/pdf/9024},
	  url   	= {https://publications.waset.org/vol/45},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 45, 2010},
	}