@article{(Open Science Index):https://publications.waset.org/pdf/8527,
	  title     = {HIV Treatment Planning on a case-by-CASE Basis},
	  author    = {Marios M. Hadjiandreou and  Raul Conejeros and  Ian Wilson},
	  country	= {},
	  institution	= {},
	  abstract     = {This study presents a mathematical modeling approach to the planning of HIV therapies on an individual basis. The model replicates clinical data from typical-progressors to AIDS for all stages of the disease with good agreement. Clinical data from rapid-progressors and long-term non-progressors is also matched by estimation of immune system parameters only. The ability of the model to reproduce these phenomena validates the formulation, a fact which is exploited in the investigation of effective therapies. The therapy investigation suggests that, unlike continuous therapy, structured treatment interruptions (STIs) are able to control the increase in both the drug-sensitive and drug-resistant virus population and, hence, prevent the ultimate progression from HIV to AIDS. The optimization results further suggest that even patients characterised by the same progression type can respond very differently to the same treatment and that the latter should be designed on a case-by-case basis. Such a methodology is presented here.
},
	    journal   = {International Journal of Bioengineering and Life Sciences},
	  volume    = {3},
	  number    = {8},
	  year      = {2009},
	  pages     = {387 - 396},
	  ee        = {https://publications.waset.org/pdf/8527},
	  url   	= {https://publications.waset.org/vol/32},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 32, 2009},
	}