%0 Journal Article
	%A Faten. A. Khorshid and  Gehan. A. Raouf and  Salem. M. El-Hamidy and  Gehan. S. Al-amri and  Nourah. A.
Alotaibi and  Taha A. Kumosani
	%D 2011
	%J International Journal of Biomedical and Biological Engineering
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 49, 2011
	%T PMF, Cesium and Rubidium Nanoparticles Induce Apoptosis in A549 Cells
	%U https://publications.waset.org/pdf/816
	%V 49
	%X Cancer becomes one of the leading cause of death in
many countries over the world. Fourier-transform infrared (FTIR)
spectra of human lung cancer cells (A549) treated with PMF (natural
product extracted from PM 701) for different time intervals were
examined. Second derivative and difference method were taken in
comparison studies. Cesium (Cs) and Rubidium (Rb) nanoparticles in
PMF were detected by Energy Dispersive X-ray attached to Scanning
Electron Microscope SEM-EDX. Characteristic changes in protein
secondary structure, lipid profile and changes in the intensities of
DNA bands were identified in treated A549 cells spectra. A
characteristic internucleosomal ladder of DNA fragmentation was
also observed after 30 min of treatment. Moreover, the pH values
were significantly increases upon treatment due to the presence of Cs
and Rb nanoparticles in the PMF fraction. These results support the
previous findings that PMF is selective anticancer agent and can
produce apoptosis to A549 cells.
	%P 20 - 27