%0 Journal Article
	%A S. Angalaparameswari and  T.S. Mohamed Saleem and  M. Alagusundaram and  S. Ramkanth and  V.S. Thiruvengadarajan and  K. Gnanaprakash and  C. Madhusudhana Chetty and  G. Pratheesh
	%D 2011
	%J International Journal of Pharmacological and Pharmaceutical Sciences
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 57, 2011
	%T Anti-microbial Activity of Aristolochic Acid from Root of Aristolochia bracteata Retz
	%U https://publications.waset.org/pdf/782
	%V 57
	%X The present research was designed to investigate the
anti-microbial activity of aristolochic acid from the root of
Aristolochia bracteata. From the methanolic & ethyl extract extracts
of Aristolochia bracteata aristolochic acid I was isolated and
conformed through IR, NMR & MS. The percentage purity of
aristolochic acid I was determined by UV & HPLC method. Antibacterial
activity of extracts of Aristolochia bracteata and the
isolated compound was determined by disc diffusion method. The
results reveled that the isolated aristolochic acid from methanolic
extract was more pure than the compound from ethyl acetate extract.
The various extracts (500μg/disc) of Aristolochia bracteata showed
moderate antibacterial activity with the average zone of inhibition of
7-18 mm by disc diffusion method. Among the extracts, ethyl acetate
& methanol extracts were shown good anti-microbial activity and the
growth of E.coli (18 mm) was strongly inhibited. Microbial assay of
isolated compound (Aristolochic acid I) from ethyl acetate &
methanol extracts were shown good antimicrobial activity and the
zone of inhibition of both at higher concentration 50 μg/ml was
similar with the standard aristolochic acid. It may be concluded that
the isolated compound of aristolochic acid I has good anti-bacterial
activity.
	%P 461 - 464