@article{(Open Science Index):https://publications.waset.org/pdf/7482,
	  title     = {A Simple Affymetrix Ratio-transformation Method Yields Comparable Expression Level Quantifications with cDNA Data},
	  author    = {Chintanu K. Sarmah and  Sandhya Samarasinghe and  Don Kulasiri and  Daniel Catchpoole},
	  country	= {},
	  institution	= {},
	  abstract     = {Gene expression profiling is rapidly evolving into a
powerful technique for investigating tumor malignancies. The
researchers are overwhelmed with the microarray-based platforms
and methods that confer them the freedom to conduct large-scale
gene expression profiling measurements. Simultaneously,
investigations into cross-platform integration methods have started
gaining momentum due to their underlying potential to help
comprehend a myriad of broad biological issues in tumor diagnosis,
prognosis, and therapy. However, comparing results from different
platforms remains to be a challenging task as various inherent
technical differences exist between the microarray platforms. In this
paper, we explain a simple ratio-transformation method, which can
provide some common ground for cDNA and Affymetrix platform
towards cross-platform integration. The method is based on the
characteristic data attributes of Affymetrix- and cDNA- platform. In
the work, we considered seven childhood leukemia patients and their
gene expression levels in either platform. With a dataset of 822
differentially expressed genes from both these platforms, we carried
out a specific ratio-treatment to Affymetrix data, which subsequently
showed an improvement in the relationship with the cDNA data.},
	    journal   = {International Journal of Biomedical and Biological Engineering},
	  volume    = {4},
	  number    = {1},
	  year      = {2010},
	  pages     = {6 - 11},
	  ee        = {https://publications.waset.org/pdf/7482},
	  url   	= {https://publications.waset.org/vol/37},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 37, 2010},
	}