M. Ramezani and S. Ghaderifard and HR. Monsef-Esfahani and S. Nasri
Effect of Geum Kokanicum Total Extract on Induced Nociception and Inflammation in Male Mice
1061 - 1063
2012
6
12
International Journal of Biotechnology and Bioengineering
https://publications.waset.org/pdf/7341
https://publications.waset.org/vol/72
World Academy of Science, Engineering and Technology
The aim of this study is evaluating the antinociceptive
and antiinflamatory activity of Geum kokanicum. After
determination total extract LD50, different doses of extract were
chosen for intrapritoneal injections. In inflammation test, male NMRI
mice were divided into 6 groups control (normal saline), positive
control (Dexamethasone 15mgkg), and total extract (0.025, 0.05,
0.1, and 0.2 grkg). The inflammation was produced by xyleneinduced
edema. In order to evaluate the antinociceptive effect of total
extract, formalin test was used. Mice were divided into 6 groups
control, positive control (morphine 10mgkg), and 4 groups which
received total extract. Then they received Formalin. The animals
were observed for the reaction to pain. Data were analyzed using
Oneway ANOVA followed by TukeyKramer multiple comparison
test. LD50 was 1 grkg. Data indicated that 0.5,0.1 and 0.2 grkg
doses of total extract have particular antinociceptive and antiinflammatory
effects in a comparison with control (P
Open Science Index 72, 2012