%0 Journal Article
	%A M. Ramezani and  S. Ghaderifard and  HR. Monsef-Esfahani and  S. Nasri
	%D 2012
	%J International Journal of Biotechnology and Bioengineering
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 72, 2012
	%T Effect of Geum Kokanicum Total Extract on Induced Nociception and Inflammation in Male Mice
	%U https://publications.waset.org/pdf/7341
	%V 72
	%X The aim of this study is evaluating the antinociceptive
and anti-inflamatory activity of Geum kokanicum. After
determination total extract LD50, different doses of extract were
chosen for intrapritoneal injections. In inflammation test, male NMRI
mice were divided into 6 groups: control (normal saline), positive
control (Dexamethasone 15mg/kg), and total extract (0.025, 0.05,
0.1, and 0.2 gr/kg). The inflammation was produced by xyleneinduced
edema. In order to evaluate the antinociceptive effect of total
extract, formalin test was used. Mice were divided into 6 groups:
control, positive control (morphine 10mg/kg), and 4 groups which
received total extract. Then they received Formalin. The animals
were observed for the reaction to pain. Data were analyzed using
One-way ANOVA followed by Tukey-Kramer multiple comparison
test. LD50 was 1 gr/kg. Data indicated that 0.5,0.1 and 0.2 gr/kg
doses of total extract have particular antinociceptive and antiinflammatory
effects in a comparison with control (P
	%P 1061 - 1063