Selvakumar Dhanasingh and Shunmuga Kumar Nallaperumal
ChitosanCasein Microparticles Preparation, Characterization and Drug Release Studies
476 - 480
2010
4
8
International Journal of Bioengineering and Life Sciences
https://publications.waset.org/pdf/6562
https://publications.waset.org/vol/44
World Academy of Science, Engineering and Technology
Microparticles carrier systems made from naturally occurring polymers based on chitosancasein system appears to be a promising carrier for the sustained release of orally and parenteral administered drugs. In the current study we followed a microencapsulation technique based aqueous coacervation method to prepare chitosancasein microparticles of compositions 11, 12 and 15 incorporated with chloramphenicol. Glutaraldehyde was used as a chemical crosslinking agent. The microparticles were prepared by aerosol method and studied by optical microscopy, infrared spectroscopy, thermo gravimetric analysis, swelling studies and drug release studies at various pH. The percentage swelling of the polymers are found to be in the order pH 4 > pH 10 > pH 7 and the increase in casein composition decrease the swelling percentage. The drug release studies also follow the above order.
Open Science Index 44, 2010