Development and Characterization of Normoxic Polyhydroxyethylacrylate (PHEA) Gel Dosimeter using Raman Spectroscopy

Authors: Aifa Afirah Rozlan, Mohamad Suhaimi Jaafar, Azhar Abdul Rahman

Abstract:

Raman spectroscopy are used to characterize the chemical changes in normoxic polyhydroxyethylacrylate gel dosimeter (PHEA) induced by radiation. Irradiations in the low dose region are performed and the polymerizations of PHEA gels are monitored by the observing the changes of Raman shift intensity of the carbon covalent bond of PHEA originated from both monomer and the cross-linker. The variation in peak intensities with absorbed dose was observed. As the dose increase, the peak intensities of covalent bond of carbon in the polymer gels decrease. This point out that the amount of absorbed dose affect the polymerization of polymer gels. As the absorbed dose increase, the polymerizations also increase. Results verify that PHEA gel dosimeters are sensitive even in lower dose region.

Keywords: normoxic polymer gel, ascorbic acid, Ramanspectroscopy, radiation dosimetry.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1062922

References:

[1] Maryanski M J, Gore J C, Kennan R P and Schulz R. NMR relaxation enhancement in gels polymerized and cross-linked by ionizing radiation: a new approach to 3-D dosimetry by MRI. Magn. Reson. Imaging. 1993; 11: 253-258.
[2] Hepworth S, Leach M O and Doran S J. Dynamics of polymerization in polyacrylamide gel (PAG) dosimeters: (II) Modeling oxygen diffusion. Phys. Med. Biol.1999; 44: 1875-1184.
[3] Fong P M, Keil D C, Does M D and John C G. Polymer gels for magnetic resonance imaging of radiation dose distributions at normal room atmosphere. Phys. Med. Biol. 2001; 46: 3105-3113.
[4] Gore J C, Ranade M, Maryanski M J, and Schulz R J. Radiation dose distribution in three dimensions from tomographic optical density scanning of polymer gel: Development of an optical scanner. Phys. Med. Biol.1996; 41: 2695-2704.
[5] Hilts M, Audet C, Duzenli C and Jirasek A. Polymer gel dosimetry using x-ray computed tomography: a feasibility study. Phys. Med. Biol. 2000; 45: 1875-1884.
[6] Baldock C, Rintoul L, Keevil S F, Pope J M and George G A. Fourier transform Raman spectroscopy of polyacrylamide gels (PAGs) for radiation dosimetry. Phys. Med. Biol. 1998; 43: 3617-3627.
[7] Gustavsson H, Back S A J, Lepage M, Rintoul L and Baldock C. Development and optimization of a 2-hydroxyethyacrylate MRI polymer gel dosimeter. Phys. Med. Biol. 2004; 49: 227-241.
[8] Jirasek A I, and Duzenli C. Effects of crosslinker fraction in polymer gel dosimeters using FT Raman Spectroscopy. Phys. Med. Biol. 2001; 46: 1949-1961.
[9] Jirasek A I, Duzenli C, Audet C and Eldridge J. Characterization of monomer/crosslinker consumption and polymer formation observed in FT-Raman spectra of irradiated polyacrylamide gels. Phys. Med. Biol. 2001; 46: 151-165.
[10] Lambert J B, Shurvell H F, Verbit L, Cooks R G and Stout G H. Organic structural analysis. New York: Macmillan Publishing Co., Inc. 1976. Part Two, Chapter 4: 234-250.
[11] De Deene Y, Hurley C, Venning A, Vergote K, Mather M, Healy B J and Baldock C. A basic study of some normoxic polymer gel dosimeters. Phys. Med. Biol. 2002; 47: 3441-3463.