%0 Journal Article
	%A Rungsinee Phongpradist and  Sawitree Chiampanichayakul and  Singkome Tima and  Teruna J. Siahaan and 
Cory J. Berkland and  Songyot Anuchapreeda and  Chadarat Ampasavate
	%D 2012
	%J International Journal of Pharmacological and Pharmaceutical Sciences
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 66, 2012
	%T Potential cIBR-Conjugated PLGA Nanoparticles for Selective Targeting to Leukemic Cells
	%U https://publications.waset.org/pdf/6057
	%V 66
	%X The expression of LFA-1 diverges from the
physiological condition, thus active targeting carrier can provide the
benefits from difference into LFA-1 expression in various conditions.
Here, the selectivity of cIBR-conjugated nanoparticles (cIBR-NPs),
in terms of uptake, was investigated using PBMCs, Mixed PBMCMolt-
3 cells and Molt-3 cells. The expressions of LFA-1 on Molt-3
cells, from flow cytometry and Western blot, possessed the highest
level whereas PBMCs showed the lowest level. The kinetic uptake
profiles of cIBR-NPs were obtained by flow cytometry, which the
degree of cellular uptake presented a similar trend with the level of
LFA-1 indicating the influence of LFA-1 expression on the cellular
uptake of cIBR-NPs. The conformation of LFA-1 had a slight effect
on the cellular uptake of cIBR-NPs. Overall we demonstrated that
cIBR-NPs enhanced cellular uptake and improved the selectivity of
drug carriers to LFA-1 on the leukemia cells, which related with the
order of LFA-1 expression.
	%P 234 - 242