@article{(Open Science Index):https://publications.waset.org/pdf/560,
	  title     = {Anticancer Effect of Doxorubicin Loaded Heparin based Super-paramagnetic Iron oxide Nanoparticles against the Human Ovarian Cancer Cells},
	  author    = {Amaneh Javid and  Shahin Ahmadian and  Ali A. Saboury and  Saeed Rezaei-Zarchi},
	  country	= {},
	  institution	= {},
	  abstract     = {This study determines the effect of naked and heparinbased
super-paramagnetic iron oxide nanoparticles on the human
cancer cell lines of A2780. Doxorubicin was used as the anticancer
drug, entrapped in the SPIO-NPs. This study aimed to decorate
nanoparticles with heparin, a molecular ligand for 'active' targeting
of cancerous cells and the application of modified-nanoparticles in
cancer treatment. The nanoparticles containing the anticancer drug
DOX were prepared by a solvent evaporation and emulsification
cross-linking method. The physicochemical properties of the
nanoparticles were characterized by various techniques, and uniform
nanoparticles with an average particle size of 110±15 nm with high
encapsulation efficiencies (EE) were obtained. Additionally, a
sustained release of DOX from the SPIO-NPs was successful.
Cytotoxicity tests showed that the SPIO-DOX-HP had higher cell
toxicity than the individual HP and confocal microscopy analysis
confirmed excellent cellular uptake efficiency. These results indicate
that HP based SPIO-NPs have potential uses as anticancer drug
carriers and also have an enhanced anticancer effect.},
	    journal   = {International Journal of Biomedical and Biological Engineering},
	  volume    = {5},
	  number    = {2},
	  year      = {2011},
	  pages     = {41 - 45},
	  ee        = {https://publications.waset.org/pdf/560},
	  url   	= {https://publications.waset.org/vol/50},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 50, 2011},
	}