@article{(Open Science Index):https://publications.waset.org/pdf/4875,
	  title     = {Ranking Genes from DNA Microarray Data of Cervical Cancer by a local Tree Comparison},
	  author    = {Frank Emmert-Streib and  Matthias Dehmer and  Jing Liu and  Max Muhlhauser},
	  country	= {},
	  institution	= {},
	  abstract     = {The major objective of this paper is to introduce a new method to select genes from DNA microarray data. As criterion to select genes we suggest to measure the local changes in the correlation graph of each gene and to select those genes whose local changes are largest. More precisely, we calculate the correlation networks from DNA microarray data of cervical cancer whereas each network represents a tissue of a certain tumor stage and each node in the network represents a gene. From these networks we extract one tree for each gene by a local decomposition of the correlation network. The interpretation of a tree is that it represents the n-nearest neighbor genes on the n-th level of a tree, measured by the Dijkstra distance, and, hence, gives the local embedding of a gene within the correlation network. For the obtained trees we measure the pairwise similarity between trees rooted by the same gene from normal to cancerous tissues. This evaluates the modification of the tree topology due to tumor progression. Finally, we rank the obtained similarity values from all tissue comparisons and select the top ranked genes. For these genes the local neighborhood in the correlation networks changes most between normal and cancerous tissues. As a result we find that the top ranked genes are candidates suspected to be involved in tumor growth. This indicates that our method captures essential information from the underlying DNA microarray data of cervical cancer.
},
	    journal   = {International Journal of Medical and Health Sciences},
	  volume    = {1},
	  number    = {2},
	  year      = {2007},
	  pages     = {138 - 143},
	  ee        = {https://publications.waset.org/pdf/4875},
	  url   	= {https://publications.waset.org/vol/2},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 2, 2007},
	}