@article{(Open Science Index):https://publications.waset.org/pdf/4123,
	  title     = {Changes of in vitro Cytokine Production induced by δ-Lactams},
	  author    = {Y. Baba hamed and  A. Medjdoub and  H. Merzouk and  M. Narce},
	  country	= {},
	  institution	= {},
	  abstract     = {The aim of this work was to study the in vitro effects
of δ-lactam 1 and its 4-chlorophenyl derivative 2, on the proliferative
responses of human lymphocytes and Th1 and Th2 cytokine
secretion. The possible protective role of vitamin E on intracellular
stress oxidative induced by these compounds was also investigated.
Peripheral blood lymphocytes were isolated using differential
centrifugation on a density gradient of Histopaque. They were
cultured with mitogen concanavalin A, vitamin E (10 μM) and with
different concentrations of the compounds 1 and 2 (0.1 to 10 μM).
Proliferation (MTT assay), IL-2, INFγ and IL-4 (Elisa kits),
intracellular superoxide anion were determined. 1 and 2 were
immunostimulant and increased cytokine secretion with a shift away
from Th1 response to Th2. These properties were however
accompanied by an increase in intracellular oxidative stress. The
presence of vitamin E exhibited protective effects by reducing δ-
lactam-induced superoxide anion generation in lymphocytes.},
	    journal   = {International Journal of Chemical and Molecular Engineering},
	  volume    = {6},
	  number    = {8},
	  year      = {2012},
	  pages     = {693 - 697},
	  ee        = {https://publications.waset.org/pdf/4123},
	  url   	= {https://publications.waset.org/vol/68},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 68, 2012},