@article{(Open Science Index):https://publications.waset.org/pdf/4030, title = {Therapeutic Product Preparation Bioprocess Modeling}, author = {Mihai Caramihai and Irina Severin and Ana Aurelia Chirvase and Adrian Onu and Cristina Tanase and Camelia Ungureanu}, country = {}, institution = {}, abstract = {An immunomodulator bioproduct is prepared in a batch bioprocess with a modified bacterium Pseudomonas aeruginosa. The bioprocess is performed in 100 L Bioengineering bioreactor with 42 L cultivation medium made of peptone, meat extract and sodium chloride. The optimal bioprocess parameters were determined: temperature – 37 0C, agitation speed - 300 rpm, aeration rate – 40 L/min, pressure – 0.5 bar, Dow Corning Antifoam M-max. 4 % of the medium volume, duration - 6 hours. This kind of bioprocesses are appreciated as difficult to control because their dynamic behavior is highly nonlinear and time varying. The aim of the paper is to present (by comparison) different models based on experimental data. The analysis criteria were modeling error and convergence rate. The estimated values and the modeling analysis were done by using the Table Curve 2D. The preliminary conclusions indicate Andrews-s model with a maximum specific growth rate of the bacterium in the range of 0.8 h-1.}, journal = {International Journal of Biomedical and Biological Engineering}, volume = {4}, number = {6}, year = {2010}, pages = {257 - 260}, ee = {https://publications.waset.org/pdf/4030}, url = {https://publications.waset.org/vol/42}, bibsource = {https://publications.waset.org/}, issn = {eISSN: 1307-6892}, publisher = {World Academy of Science, Engineering and Technology}, index = {Open Science Index 42, 2010}, }