Chien-Hung Huang and Chia-Wei Weng and Chang-Chih Chiang and Shih-Hua Wu and Chih-Hsien Huang and Ka-Lok Ng
A study of Cancerrelated MicroRNAs through Expression Data and Literature Search
918 - 920
2009
3
4
International Journal of Computer and Information Engineering
https://publications.waset.org/pdf/3278
https://publications.waset.org/vol/28
World Academy of Science, Engineering and Technology
MicroRNAs (miRNAs) are a class of noncoding
RNAs that hybridize to mRNAs and induce either translation
repression or mRNA cleavage. Recently, it has been reported that
miRNAs could possibly play an important role in human diseases. By
integrating miRNA target genes, cancer genes, miRNA and mRNA
expression profiles information, a database is developed to link
miRNAs to cancer target genes. The database provides experimentally
verified human miRNA target genes information, including oncogenes
and tumor suppressor genes. In addition, fragile sites information for
miRNAs, and the strength of the correlation of miRNA and its target
mRNA expression level for nine tissue types are computed, which
serve as an indicator for suggesting miRNAs could play a role in
human cancer. The database is freely accessible at
httpppi.bioinfo.asia.edu.twmirna_targetindex.html.
Open Science Index 28, 2009