@article{(Open Science Index):https://publications.waset.org/pdf/2943,
	  title     = {Neuroblasts Micropatterning on Nanostructural Modified Chitosan Membranes},
	  author    = {Chun-Yen Sung and  Chung-Yao Yang and  Tzu-Chun Liao and  Wen-Shiang Chen and  Chao-Min Cheng and  J. Andrew Yeh},
	  country	= {},
	  institution	= {},
	  abstract     = {The study describes chitosan membrane platform
modified with nanostructure pattern which using nanotechnology to
fabricate. The cell-substrate interaction between neuro-2a neuroblasts
cell lines and chitosan membrane (flat, nanostructure and
nanostructure pattern types) was investigated. The adhered
morphology of neuro-2a cells depends on the topography of chitosan
surface. We have found that neuro-2a showed different morphogenesis
when cells adhered on flat and nanostructure chitosan membrane. The
cell projected area of neuro-2a on flat chitosan membrane is larger
than on nanostructure chitosan membrane. In addition, neuro-2a cells
preferred to adhere on flat chitosan surface region than on
nanostructure chitosan membrane to immobilize and differentiation.
The experiment suggests surface topography can be used as a critical
mechanism to isolate group of neuro-2a to a particular rectangle area
on chitosan membrane. Our finding will provide a platform to take
patch clamp to record electrophysiological behavior about neurons in
vitro in the future.},
	    journal   = {International Journal of Biomedical and Biological Engineering},
	  volume    = {7},
	  number    = {2},
	  year      = {2013},
	  pages     = {91 - 94},
	  ee        = {https://publications.waset.org/pdf/2943},
	  url   	= {https://publications.waset.org/vol/74},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 74, 2013},
	}