TY - JFULL AU - M. Michael Gromiha and Y. Yabuki and K. Imai and P. Horton and K. Fukui PY - 2009/2/ TI - Database Development and Discrimination Algorithms for Membrane Protein Functions T2 - International Journal of Computer and Information Engineering SP - 46 EP - 51 VL - 3 SN - 1307-6892 UR - https://publications.waset.org/pdf/2658 PU - World Academy of Science, Engineering and Technology NX - Open Science Index 25, 2009 N2 - We have developed a database for membrane protein functions, which has more than 3000 experimental data on functionally important amino acid residues in membrane proteins along with sequence, structure and literature information. Further, we have proposed different methods for identifying membrane proteins based on their functions: (i) discrimination of membrane transport proteins from other globular and membrane proteins and classifying them into channels/pores, electrochemical and active transporters, and (ii) β-signal for the insertion of mitochondrial β-barrel outer membrane proteins and potential targets. Our method showed an accuracy of 82% in discriminating transport proteins and 68% to classify them into three different transporters. In addition, we have identified a motif for targeting β-signal and potential candidates for mitochondrial β-barrel membrane proteins. Our methods can be used as effective tools for genome-wide annotations. ER -