@article{(Open Science Index):https://publications.waset.org/pdf/2612,
	  title     = {Combining Gene and Chemo Therapy using Multifunctional Polymeric Micelles},
	  author    = {Hong Yi Huang and  Wei Ti Kuo and  Yi You Huang},
	  country	= {},
	  institution	= {},
	  abstract     = {Non-viral gene carriers composed of biodegradable
polymers or lipids have been considered as a safer alternative for gene
carriers over viral vectors. We have developed multi-functional
nano-micelles for both drug and gene delivery application.
Polyethyleneimine (PEI) was modified by grafting stearic acid (SA)
and formulated to polymeric micelles (PEI-SA) with positive surface
charge for gene and drug delivery. Our results showed that PEI-SA
micelles provided high siRNA binding efficiency. In addition, siRNA
delivered by PEI-SA carriers also demonstrated significantly high
cellular uptake even in the presence of serum proteins. The
post-transcriptional gene silencing efficiency was greatly improved by
the polyplex formulated by 10k PEI-SA/siRNA. The amphiphilic
structure of PEI-SA micelles provided advantages for multifunctional
tasks; where the hydrophilic shell modified with cationic charges can
electrostatically interact with DNA or siRNA, and the hydrophobic
core can serve as payloads for hydrophobic drugs, making it a
promising multifunctional vehicle for both genetic and chemotherapy
	    journal   = {International Journal of Biomedical and Biological Engineering},
	  volume    = {4},
	  number    = {5},
	  year      = {2010},
	  pages     = {240 - 243},
	  ee        = {https://publications.waset.org/pdf/2612},
	  url   	= {https://publications.waset.org/vol/41},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 41, 2010},