@article{(Open Science Index):https://publications.waset.org/pdf/2272,
	  title     = {Introducing Sequence-Order Constraint into Prediction of Protein Binding Sites with Automatically Extracted Templates},
	  author    = {Yi-Zhong Weng and  Chien-Kang Huang and  Yu-Feng Huang and  Chi-Yuan Yu and  Darby Tien-Hao Chang},
	  country	= {},
	  institution	= {},
	  abstract     = {Search for a tertiary substructure that geometrically
matches the 3D pattern of the binding site of a well-studied protein provides a solution to predict protein functions. In our previous work,
a web server has been built to predict protein-ligand binding sites
based on automatically extracted templates. However, a drawback of such templates is that the web server was prone to resulting in many
false positive matches. In this study, we present a sequence-order constraint to reduce the false positive matches of using automatically
extracted templates to predict protein-ligand binding sites. The binding site predictor comprises i) an automatically constructed template library and ii) a local structure alignment algorithm for
querying the library. The sequence-order constraint is employed to
identify the inconsistency between the local regions of the query protein and the templates. Experimental results reveal that the sequence-order constraint can largely reduce the false positive matches and is effective for template-based binding site prediction.},
	    journal   = {International Journal of Computer and Information Engineering},
	  volume    = {3},
	  number    = {5},
	  year      = {2009},
	  pages     = {1456 - 1462},
	  ee        = {https://publications.waset.org/pdf/2272},
	  url   	= {https://publications.waset.org/vol/29},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 29, 2009},