@article{(Open Science Index):https://publications.waset.org/pdf/16309, title = {Cutaneous Application of Royal Jelly Inhibits Skin Lesions in NC/Nga Mice, a Human-Like Mouse Model of Atopic Dermatitis}, author = {Junki Miyamoto and Mariko Kiyomi and Yuuki Nagashio and Takuya Suzuki and Soichi Tanabe}, country = {}, institution = {}, abstract = {Anti-allergic effects of royal jelly were evaluated in a human-like mouse model of atopic dermatitis. NC/Nga mice were cutaneously applied with royal jelly for 6 weeks. Royal jelly-treated mice exhibited lower levels of serum total immunoglobulin E in comparison with controls. We found that the treatment decreased (11% to the control) expression of mRNA for aquaporin-3, which is involved in the modulation of epidermal hydration. Microarray analysis revealed more than 10-fold changes in the expression of several genes, such as transglutaminase 2, repetin, and keratins. In normal human epidermal keratinocytes, royal jelly extract suppressed interleukin-8 elevation induced by TNF-α and interferon-γ, suggesting direct anti-inflammatory activity in keratinocytes. Collectively, topical application of royal jelly may be useful for amelioration of lesions and inflammation in atopic dermatitis. }, journal = {International Journal of Medical and Health Sciences}, volume = {7}, number = {7}, year = {2013}, pages = {361 - 364}, ee = {https://publications.waset.org/pdf/16309}, url = {https://publications.waset.org/vol/79}, bibsource = {https://publications.waset.org/}, issn = {eISSN: 1307-6892}, publisher = {World Academy of Science, Engineering and Technology}, index = {Open Science Index 79, 2013}, }