@article{(Open Science Index):https://publications.waset.org/pdf/16309,
	  title     = {Cutaneous Application of Royal Jelly Inhibits Skin Lesions in NC/Nga Mice, a Human-Like Mouse Model of Atopic Dermatitis},
	  author    = {Junki Miyamoto and  Mariko Kiyomi and  Yuuki Nagashio and  Takuya Suzuki and  Soichi Tanabe},
	  country	= {},
	  institution	= {},
	  abstract     = {Anti-allergic effects of royal jelly were evaluated in a human-like mouse model of atopic dermatitis. NC/Nga mice were cutaneously applied with royal jelly for 6 weeks. Royal jelly-treated mice exhibited lower levels of serum total immunoglobulin E in comparison with controls. We found that the treatment decreased (11% to the control) expression of mRNA for aquaporin-3, which is involved in the modulation of epidermal hydration. Microarray analysis revealed more than 10-fold changes in the expression of several genes, such as transglutaminase 2, repetin, and keratins. In normal human epidermal keratinocytes, royal jelly extract suppressed interleukin-8 elevation induced by TNF-α and interferon-γ, suggesting direct anti-inflammatory activity in keratinocytes. Collectively, topical application of royal jelly may be useful for amelioration of lesions and inflammation in atopic dermatitis.
},
	    journal   = {International Journal of Medical and Health Sciences},
	  volume    = {7},
	  number    = {7},
	  year      = {2013},
	  pages     = {361 - 364},
	  ee        = {https://publications.waset.org/pdf/16309},
	  url   	= {https://publications.waset.org/vol/79},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 79, 2013},
	}