Quality Fed-Batch Bioprocess Control A Case Study

Authors: Mihai Caramihai, Irina Severin

Abstract:

Bioprocesses are appreciated as difficult to control because their dynamic behavior is highly nonlinear and time varying, in particular, when they are operating in fed batch mode. The research objective of this study was to develop an appropriate control method for a complex bioprocess and to implement it on a laboratory plant. Hence, an intelligent control structure has been designed in order to produce biomass and to maximize the specific growth rate.

Keywords: Fed batch bioprocess, mass-balance model, fuzzy control

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1335324

References:

[1] R. Oliveira, Comp. & Chem. Eng., 28 (2004), 755.
[2] M. Jench, S. Gnoth, M. Beck, M. Kleinschmidt, R. Simutis, A. Lubbert, J. Biotech, 127 (2006), 84.
[3] C. Komives, R. S. Parker, Curr. Opinion Biotech, 14(2003), 468.
[4] J.Ichi Horiuchi, J. Biosc Bioeng, 94(2002), 574.
[5] V. Vojinovic, J. M. S. Cabral, L. P. Fonseca, Sensors & Actuators B, 114(2006), 1083.
[6] F. Renard, A. et all, J. Process Contr.
[7] E. K. Junso, J. Knolof, 16th IFAC W. Congress, Prague, 2005, Topic 8.4.
[8] K. Schugerl, K. H. Bellgardt, Bioreact. Eng, Springer Verlag, Berlin, 2000.