%0 Journal Article
	%A Mohammad Sadeghi and  Behrouz Heidari and  Korush Montazeri
	%D 2011
	%J International Journal of Chemical and Molecular Engineering
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 52, 2011
	%T Design a Biodegradable Hydrogel for Drug Delivery System
	%U https://publications.waset.org/pdf/13806
	%V 52
	%X In this article, we synthesize a novel chitosan -based
superabsorbent hydrogel via graft copolymerization of mixtures
acrylic acid (AA) and N-vinyl pyrollidon onto chitosan backbones.
The polymerization reaction was carried out in an aqueous medium
and in the presence of ammonium persulfate (APS) as an initiator and
N,N'-methylene bisacrylamide (MBA) as a crosslinker.The hydrogel
structures were confirmed by FTIR spectroscopy. The swelling
behavior of these absorbent polymers was also investigated in
various salt solutions. Results indicated that the swelling capacity
decreased with an increase in the ionic strength of the swelling
medium. Furthermore, the swelling of superabsorbing hydrogels was
examined in solutions with pH values ranging between 1.0 and 13.0.
It showed a reversible pH-responsive behavior at pHs 2.0 and 8.0.
This on-off switching behavior makes the synthesized hydrogels as
an excellent candidate for controlled delivery of bioactive agents.
	%P 319 - 321