L. Labéjof and I. Mororó and P. Galle and G. Barbosa and M.I. Severo and A.H. de Oliveira
Effect of Dose Rate of Irradiation on Ultrastructure of Duodenal Mucosa
492 - 499
2010
4
8
International Journal of Biotechnology and Bioengineering
https://publications.waset.org/pdf/1324
https://publications.waset.org/vol/44
World Academy of Science, Engineering and Technology
Ultrastructure of duodenum mucosa of irradiated rat
was studied versus dose rate of irradiation following exposure to
gamma rays from 60Cobalt source. The animals were whole body
irradiated at two dose rates (1 Gy.mn1 and 1 Gy.h1) and three total
doses (1, 2 or 4 Gy) for each dose rate. 24 or 48 h after irradiation,
their small intestine was removed and samples of duodenum were
processed for observations under a transmission electron microscopy.
Samples of duodenum mucosa of control rats were processed in the
same way. For the lower dose rate of 1 Gy.h1, main lesions
characteristic of apoptosis were detected within irradiated enterocytes
at a total dose of 2 Gy and 24 h after exposure. Necrosis was noted in
the samples, 48 h after exposition. For the higher dose rate of 1
Gy.mn1, fewer changes were detected at all total doses 24 or 48 h
irradiation. Thus, it was shown that the appearance of radiationinduced
alterations varies not only with increasing total dose and
postirradiation time but especially with decreasing dose rate.
Open Science Index 44, 2010