%0 Journal Article
	%A L. Labéjof and  I. Mororó and  P. Galle and  G. Barbosa and  M.I. Severo and  A.H. de Oliveira
	%D 2010
	%J International Journal of Biotechnology and Bioengineering
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 44, 2010
	%T Effect of Dose Rate of Irradiation on Ultrastructure of Duodenal Mucosa
	%U https://publications.waset.org/pdf/1324
	%V 44
	%X Ultrastructure of duodenum mucosa of irradiated rat
was studied versus dose rate of irradiation following exposure to
gamma rays from 60-Cobalt source. The animals were whole body
irradiated at two dose rates (1 Gy.mn-1 and 1 Gy.h-1) and three total
doses (1, 2 or 4 Gy) for each dose rate. 24 or 48 h after irradiation,
their small intestine was removed and samples of duodenum were
processed for observations under a transmission electron microscopy.
Samples of duodenum mucosa of control rats were processed in the
same way. For the lower dose rate of 1 Gy.h-1, main lesions
characteristic of apoptosis were detected within irradiated enterocytes
at a total dose of 2 Gy and 24 h after exposure. Necrosis was noted in
the samples, 48 h after exposition. For the higher dose rate of 1
Gy.mn-1, fewer changes were detected at all total doses 24 or 48 h
irradiation. Thus, it was shown that the appearance of radiationinduced
alterations varies not only with increasing total dose and
post-irradiation time but especially with decreasing dose rate.
	%P 492 - 499