@article{(Open Science Index):https://publications.waset.org/pdf/1324, title = {Effect of Dose Rate of Irradiation on Ultrastructure of Duodenal Mucosa}, author = {L. Labéjof and I. Mororó and P. Galle and G. Barbosa and M.I. Severo and A.H. de Oliveira}, country = {}, institution = {}, abstract = {Ultrastructure of duodenum mucosa of irradiated rat was studied versus dose rate of irradiation following exposure to gamma rays from 60-Cobalt source. The animals were whole body irradiated at two dose rates (1 Gy.mn-1 and 1 Gy.h-1) and three total doses (1, 2 or 4 Gy) for each dose rate. 24 or 48 h after irradiation, their small intestine was removed and samples of duodenum were processed for observations under a transmission electron microscopy. Samples of duodenum mucosa of control rats were processed in the same way. For the lower dose rate of 1 Gy.h-1, main lesions characteristic of apoptosis were detected within irradiated enterocytes at a total dose of 2 Gy and 24 h after exposure. Necrosis was noted in the samples, 48 h after exposition. For the higher dose rate of 1 Gy.mn-1, fewer changes were detected at all total doses 24 or 48 h irradiation. Thus, it was shown that the appearance of radiationinduced alterations varies not only with increasing total dose and post-irradiation time but especially with decreasing dose rate.}, journal = {International Journal of Biotechnology and Bioengineering}, volume = {4}, number = {8}, year = {2010}, pages = {492 - 499}, ee = {https://publications.waset.org/pdf/1324}, url = {https://publications.waset.org/vol/44}, bibsource = {https://publications.waset.org/}, issn = {eISSN: 1307-6892}, publisher = {World Academy of Science, Engineering and Technology}, index = {Open Science Index 44, 2010}, }