@article{(Open Science Index):https://publications.waset.org/pdf/1316, title = {Highly Sensitive Label Free Biosensor for Tumor Necrosis Factor}, author = {Tze Sian Pui and Tushar Bansal and Patthara Kongsuphol and Sunil K. Arya}, country = {}, institution = {}, abstract = {We present a label-free biosensor based on electrochemical impedance spectroscopy for the detection of proinflammatory cytokine Tumor Necrosis Factor (TNF-α). Secretion of TNF-α has been correlated to the onset of various diseases including rheumatoid arthritis, Crohn-s disease etc. Gold electrodes were patterned on a silicon substrate and self assembled monolayer of dithiobis-succinimidyl propionate was used to develop the biosensor which achieved a detection limit of ~57fM. A linear relationship was also observed between increasing TNF-α concentrations and chargetransfer resistance within a dynamic range of 1pg/ml – 1ng/ml.}, journal = {International Journal of Biomedical and Biological Engineering}, volume = {6}, number = {9}, year = {2012}, pages = {443 - 446}, ee = {https://publications.waset.org/pdf/1316}, url = {https://publications.waset.org/vol/69}, bibsource = {https://publications.waset.org/}, issn = {eISSN: 1307-6892}, publisher = {World Academy of Science, Engineering and Technology}, index = {Open Science Index 69, 2012}, }