Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 30455
Evaluation of Radiation Synthesized β-Glucan Hydrogel Wound Dressing using Rat Models

Authors: Hui J. Gwon, Youn M. Lim, Jong S. Park, Young C. Nho

Abstract:

In this study, hydrogels consisted of polyvinyl alcohol, propylene glycol and β-glucan were developed by radiation technique for wound dressing. The prepared hydrogels were characterized by examining of physical properties such as gel fraction and absorption ratio. The gel fraction and absorption ratio were dependent on the crosslinking density. On observing the wound healing of rat skin, the resulting hydrogels accelerated the wound healing comparing to cotton gauze. Therefore, the PVA/propylene glycol/β-glucan blended hydrogels can greatly accelerate the healing without causing irritation.

Keywords: Radiation, Wound Dressing, poly(vinyl alcohol), β-glucan, propylene glycol

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1334814

Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 4304

References:


[1] H. J. Gwon, Y. M. Lim, Y. C. Nho, J. W. Shim, I. K. Kwon, H. N. Chang, and S. E. Kim, "New route for synthesizing poly(ethylene glycol)-acrylic Acid hydrogels using ╬│-irradiation for drug delivery carriers", Biotech. Bioproc. Eng., vol. 15, pp. 392-399, 2010.
[2] N. A. Peppas and E. W. Merrill, "Differential scanning calorimetry of crystallized PVA hydrogels", J. Appl. Polym. Sci., vol. 20, no. 6, pp. 1457−1465, 1976.
[3] G. D. Winter, "Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig". Nature, vol. 193, pp. 293-294, 1962.
[4] H. J. Gwon, Y. M. Lim, Y. C. Nho, and S. H. Baik, "Humectants effect on aqueous fluids absorption of ╬│-irradiated PVA hydrogel followed by freeze thawing", Radiat. Phys. Chem., vol. 79, pp. 650-653, 2010.
[5] J. M. Rosiak, "Radiation formation of hydrogels for drug delivery", J. Control. Release, vol. 31, pp. 9−19, 1994.
[6] C. M. Hassan, J. E. Stewart, and N. A. Peppas, "Diffusional characteristics of freeze/thawed PVA hydrogels: applications to protein controlled release from multilaminate devices," Europ. J. Pharm. Biopharm., vol. 49, pp. 161−166, 2000.
[7] H. Matsuyama, M. Teramoto, and H. Urano, "Analysis of solute diffusion in poly(vinyl alcohol) hydrogel membrane", J. Membrane Sci., vol. 126, pp. 151−160, 1997.
[8] K. Burczak, T. Fujisato, M. Hatada, and Y. Ikada, "Protein permeation through poly(vinyl alcohol) hydrogels membranes", Biomaterials, vol. 15, no. 3, pp. 231−238, 1994.
[9] A. Hoelgaarda and B. Mollgaarda, "Dermal drug delivery: Improvement by choice of vehicle or drug derivative", J. Control. Release, vol. 2, pp. 111-120, 1985.
[10] J. M. Rosiak, "Radiation formation of hydrogels for drug delivery", J. Control. Release, vol. 31, pp. 9−19, 1994.
[11] A. T. Borchers, C. L. Keen, and M. E. Gershwin, "Mushrooms, tumors, and immunity: An update", Exp. Biol. Med. Vol. 229, pp. 393−406, 2004.
[12] S. B. Lee, H. W. Jeon, Y. W. Lee, Y. M. Lee, K. W. Song, M. H. Park, Y. S. Nam, and H. C. Ahn, "Bio-artificial skin composed of gelatin and (1  3), (1 6)-beta-glucan", Biomaterials, vol. 24, no. 14, pp. 2503-2511,2003.
[13] J. M. Rosiak and P. Ulanski, "Synthesis of hydrogels by irradiation of polymers in aqueous solution", Radiat. Phys. Chem., vol. 55, pp. 139−151, 1999.
[14] Y. Xiaomin, L. Qi, C. Xiliang, and Z. Zhiyong, "Investigation on the formation mechanisms of hydrogels made by combination of ╬│-ray irradiation and freeze-thawing", J. Appl. Polym. Sci., vol. 108, pp. 1365-1372, 2008.