@article{(Open Science Index):https://publications.waset.org/pdf/1199,
	  title     = {Growth Effects of Caffeic Acid and Thioglycolic Acid Modified Chitosans in U937 Cells},
	  author    = {Aytekin A.O. and  Morimura S.},
	  country	= {},
	  institution	= {},
	  abstract     = {Chitosan is a biopolymer composed of glucosamine
and N-acetyl glucosamine. Solubility and viscosity pose problems in
some applications. These problems can be overcome with unique
modifications. In this study, firstly, chitosan was modified by caffeic
acid and thioglycolic acid, separately. Then, growing effects of these
modified polymers was observed in U937 cell line. Caffeic acid is a
phenolic compound and its modifications act carcinogenic inhibitors
in drugs. Thiolated chitosans are commonly being used for drugdelivery
systems in various routes, because of enhancing
mucoadhesiveness property. U937 cell line was used model cell for
leukaemia. Modifications were achieved by 1 – 15 % binding range.
Increasing binding ratios showed higher radical-scavenging activity
and reducing cell growth, in compared to native chitosan. Caffeic
acid modifications showed higher radical-scavenging activity than
thiolated chitosans at the same concentrations. Caffeic acid and
thioglycolic acid modifications inhibited growth of U937, effectively.},
	    journal   = {International Journal of Chemical and Molecular Engineering},
	  volume    = {4},
	  number    = {5},
	  year      = {2010},
	  pages     = {325 - 329},
	  ee        = {https://publications.waset.org/pdf/1199},
	  url   	= {https://publications.waset.org/vol/41},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 41, 2010},