%0 Journal Article
	%A Liansheng Ren and  Xihua Yang and  Guoping Wang and  Hong Zhang and  Lili Zhao and  Zhenguo Mi
	%D 2011
	%J International Journal of Medical and Health Sciences
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 60, 2011
	%T Inhibition Effect of Brazilin to Human Bladder Cancer Cell Line T24
	%U https://publications.waset.org/pdf/11612
	%V 60
	%X The inhibition effect of brazilin to human bladder
tumor cell line T24 in vitro and in vivo was studied. The results of the
in vitro experiments showed that brazilin has strong inhibition activity
on the target cells. The inhibition ratio of 100 μg/mL brazilin and 100
μg/mL mitomycin to the target cells was 90.90 % and 63.24 %
respectively, which showed that brazilin has higher inhibition activity
than mitomycin under the same concentration. Brazilin could induce
cell apoptosis in T24 cells. Significant antitumor activity of brazilin
was also showed in the animals experiments. The life extention rate of
200 mg/mL, 300 mg/kg, and 400 mg/kg brazilin intraperitoneally
injected into Balb/c-nu-nu nude mice that with human bladder cancer
were 51.50 %, 56.90 %, and 58.42 %（P
	%P 657 - 661