@article{(Open Science Index):https://publications.waset.org/pdf/11612, title = {Inhibition Effect of Brazilin to Human Bladder Cancer Cell Line T24}, author = {Liansheng Ren and Xihua Yang and Guoping Wang and Hong Zhang and Lili Zhao and Zhenguo Mi}, country = {}, institution = {}, abstract = {The inhibition effect of brazilin to human bladder tumor cell line T24 in vitro and in vivo was studied. The results of the in vitro experiments showed that brazilin has strong inhibition activity on the target cells. The inhibition ratio of 100 μg/mL brazilin and 100 μg/mL mitomycin to the target cells was 90.90 % and 63.24 % respectively, which showed that brazilin has higher inhibition activity than mitomycin under the same concentration. Brazilin could induce cell apoptosis in T24 cells. Significant antitumor activity of brazilin was also showed in the animals experiments. The life extention rate of 200 mg/mL, 300 mg/kg, and 400 mg/kg brazilin intraperitoneally injected into Balb/c-nu-nu nude mice that with human bladder cancer were 51.50 %, 56.90 %, and 58.42 %(P}, journal = {International Journal of Medical and Health Sciences}, volume = {5}, number = {12}, year = {2011}, pages = {657 - 661}, ee = {https://publications.waset.org/pdf/11612}, url = {https://publications.waset.org/vol/60}, bibsource = {https://publications.waset.org/}, issn = {eISSN: 1307-6892}, publisher = {World Academy of Science, Engineering and Technology}, index = {Open Science Index 60, 2011}, }