%0 Journal Article %A Tudor Petreuş and Andrei Neamţu and Cristina Dascălu and Paul Dan Sîrbu and Carmen E. Cotrutz %D 2010 %J International Journal of Structural and Construction Engineering %B World Academy of Science, Engineering and Technology %I Open Science Index 44, 2010 %T Molecular Docking on Recomposed versus Crystallographic Structures of Zn-Dependent Enzymes and their Natural Inhibitors %U https://publications.waset.org/pdf/10995 %V 44 %X Matrix metalloproteinases (MMP) are a class of structural and functional related enzymes involved in altering the natural elements of the extracellular matrix. Most of the MMP structures are cristalographycally determined and published in WorldWide ProteinDataBank, isolated, in full structure or bound to natural or synthetic inhibitors. This study proposes an algorithm to replace missing crystallographic structures in PDB database. We have compared the results of a chosen docking algorithm with a known crystallographic structure in order to validate enzyme sites reconstruction there where crystallographic data are missing. %P 664 - 667