@article{(Open Science Index):https://publications.waset.org/pdf/10858,
	  title     = {Cannabidiol Treatment Ameliorates Acetaminophen-Induced Hepatotoxicity in Mice},
	  author    = {Amr A. Fouad and  Waleed H. Albuali and  Iyad Jresat},
	  country	= {},
	  institution	= {},
	  abstract     = {The possible therapeutic effect of cannabidiol, the major non-psychotropic Cannabis constituent, was investigated against acute hepatotoxicity induced by a single oral dose of acetaminophen (500mg/kg) in mice. Cannabidiol (two intraperitoneal injections, 5mg/kg, each) was given 1 hour and 12 hours following acetaminophen administration. Acetaminophen administration caused significant elevations of serum alanine aminotransferase, and hepatic malondialdehyde, and nitric oxide levels, and a significant decrease in hepatic reduced glutathione. Cannabidiol significantly attenuated the deterioration in the measured biochemical parameters resulted from acetaminophen administration. Also, histopathological examination showed that cannabidiol markedly attenuated ameliorated acetaminophen-induced liver tissue damage. These results emphasize that cannabidiol represents a potential therapeutic option to protect against acetaminophen hepartotoxicity which is a common clinical problem.
},
	    journal   = {International Journal of Pharmacological and Pharmaceutical Sciences},
	  volume    = {7},
	  number    = {6},
	  year      = {2013},
	  pages     = {240 - 243},
	  ee        = {https://publications.waset.org/pdf/10858},
	  url   	= {https://publications.waset.org/vol/78},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 78, 2013},
	}