@article{(Open Science Index):https://publications.waset.org/pdf/10858, title = {Cannabidiol Treatment Ameliorates Acetaminophen-Induced Hepatotoxicity in Mice}, author = {Amr A. Fouad and Waleed H. Albuali and Iyad Jresat}, country = {}, institution = {}, abstract = {The possible therapeutic effect of cannabidiol, the major non-psychotropic Cannabis constituent, was investigated against acute hepatotoxicity induced by a single oral dose of acetaminophen (500mg/kg) in mice. Cannabidiol (two intraperitoneal injections, 5mg/kg, each) was given 1 hour and 12 hours following acetaminophen administration. Acetaminophen administration caused significant elevations of serum alanine aminotransferase, and hepatic malondialdehyde, and nitric oxide levels, and a significant decrease in hepatic reduced glutathione. Cannabidiol significantly attenuated the deterioration in the measured biochemical parameters resulted from acetaminophen administration. Also, histopathological examination showed that cannabidiol markedly attenuated ameliorated acetaminophen-induced liver tissue damage. These results emphasize that cannabidiol represents a potential therapeutic option to protect against acetaminophen hepartotoxicity which is a common clinical problem. }, journal = {International Journal of Pharmacological and Pharmaceutical Sciences}, volume = {7}, number = {6}, year = {2013}, pages = {240 - 243}, ee = {https://publications.waset.org/pdf/10858}, url = {https://publications.waset.org/vol/78}, bibsource = {https://publications.waset.org/}, issn = {eISSN: 1307-6892}, publisher = {World Academy of Science, Engineering and Technology}, index = {Open Science Index 78, 2013}, }