@article{(Open Science Index):https://publications.waset.org/pdf/10011761, title = {Green, Smooth and Easy Electrochemical Synthesis of N-Protected Indole Derivatives}, author = {Sarah Fahad Alajmi and Tamer Ezzat Youssef}, country = {}, institution = {}, abstract = {Here, we report a simple method for the direct conversion of 6-Nitro-1H-indole into N-substituted indoles via electrochemical dehydrogenative reaction with halogenated reagents under strongly basic conditions through N–R bond formation. The N-protected indoles have been prepared under moderate and scalable electrolytic conditions. The conduct of the reactions was performed in a simple divided cell under constant current without oxidizing reagents or transition-metal catalysts. The synthesized products have been characterized via UV/Vis spectrophotometry, 1H-NMR, and FTIR spectroscopy. A possible reaction mechanism is discussed based on the N-protective products. This methodology could be applied to the synthesis of various biologically active N-substituted indole derivatives. }, journal = {International Journal of Chemical and Molecular Engineering}, volume = {15}, number = {1}, year = {2021}, pages = {5 - 9}, ee = {https://publications.waset.org/pdf/10011761}, url = {https://publications.waset.org/vol/169}, bibsource = {https://publications.waset.org/}, issn = {eISSN: 1307-6892}, publisher = {World Academy of Science, Engineering and Technology}, index = {Open Science Index 169, 2021}, }