{"title":"Effect of Span 60, Labrasol, and Cholesterol on Labisia pumila Loaded Niosomes Quality","authors":"H. Binti Ya\u2019akob, C. Siew Chin, A. Abd Aziz, I. Ware, M. Fauzi Abd Jalil, N. Rashidah Ahmed, R. Sabtu","volume":127,"journal":"International Journal of Biotechnology and Bioengineering","pagesStart":521,"pagesEnd":525,"ISSN":"1307-6892","URL":"https:\/\/publications.waset.org\/pdf\/10007586","abstract":"
Labisia pumila<\/em> (LP) plant extract has the potential to be applied in cosmeceutical products due to its anti-photoaging properties. The main purpose of this study was to improve transdermal delivery of LP by encapsulating LP in niosomes. Niosomes loaded LPs were prepared by coacervation phase separation method using non-ionic surfactant (Span 60), labrasol, and cholesterol. The optimum formula obtained were Span 60, labrasol and cholesterol at the mole ratio of 6:1:4. At the optimum formulation, the niosome obtained significantly improved the quality of transdermal penetration of LP compared to free LP.<\/p>\r\n","references":"[1]\tC. Manach, A. Scalbert, C. Morand, C. R\u00e9m\u00e9sy, and L. Jim\u00e9nez, Am, \u201cPolyphenols: food sources and bioavailability,\u201d J. Clin. Nutr., 79 (5), 727\u201347 (2004).\r\n[2]\tG. S. Asthana, P. K. Sharma, and A. Asthana, \u201cIn Vitro and In Vivo Evaluation of Niosomal Formulation for Controlled Delivery of Clarithromycin\u201d, Scientifica, 2016, 6492953 (2016).\r\n[3]\tH. Choi, D. Kim, J. W. Kim, S. Ngadiran, M. R. Sarmidi, and C. S. Park, \u201cLabisia pumila extract protects skin cells from photoaging caused by UVB irradiation,\u201d J. Biosci. Bioeng., 109 (3), 291\u20136 (2010).\r\n[4]\tM. R. Sulaiman, M. K. Hussain, Z. A. Zakaria, M. N. Somchit, and S. Moin, \u201cEvaluation of the antinociceptive activity of Ficus deltoidea aqueous extract Fitoterapia\u201d, 79, 557\u2013561 (2008).\r\n[5]\tB. Vora, A. Khopade, and N. Jain, \u201cProniosome based transdermal delivery of levonorgestrel for effective contraception,\u201d J. Control. release, 54, 149\u2013165 (1998).\r\n[6]\tD. Fry, J. White, and I. Goldman, \u201cRapid separation of low molecular weight solutes from liposomes without dilution,\u201d Anal. Biochem., 90 (2), 809\u2013815 (1978).\r\n[7]\tK. A. Shah, A. A. Date, M. D. Joshi, and V. B. Patravale, \u201cSolid lipid nanoparticles (SLN) of tretinoin: potential in topical delivery,\u201d Int. J. Pharm., 345 (1\u20132), 163\u2013171(2007).\r\n[8]\tJ. Misik, R. Pavlikova, J. Cabal, L. Novotny, and K. Kuca, \u201cOriginal article method of static diffusion cells for assessment of pesticides skin permeation,\u201d Mil. Med. Sci. Lett., 80, 46\u201351(2011).\r\n[9]\tA. C. Sintov and L. Shapiro, \u201cNew microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo\u201d J. Control. Release, 95 (2), 173\u2013183 (2004).\r\n[10]\tM. Kong, X. G. Chen, D. K. Kweon, and H. J. Park, \u201cInvestigations on skin permeation of hyaluronic acid based nanoemulsion as transdermal carrier,\u201d Carbohydr. Polym., 86 (2), 837\u2013843(2011).","publisher":"World Academy of Science, Engineering and Technology","index":"Open Science Index 127, 2017"}