@article{(Open Science Index):https://publications.waset.org/pdf/10004542,
	  title     = {Carvacrol Attenuates Lung Injury in Rats with Severe Acute Pancreatitis},
	  author    = {Salim Cerig and  Fatime Geyikoglu and  Pınar Akpulat and  Suat Colak and  Hasan Turkez and  Murat Bakir and  Mirkhalil Hosseinigouzdagani and  Kubra Koc},
	  country	= {},
	  institution	= {},
	  abstract     = {This study was designed to evaluate whether carvacrol
(CAR) could provide protection against lung injury by acute
pancreatitis development. The rats were randomized into groups to
receive (I) no therapy; (II) 50 μg/kg cerulein at 1h intervals by four
intraperitoneal injections (i.p.); (III) 50, 100 and 200 mg/kg CAR by
one i.p.; and (IV) cerulein+CAR after 2h of cerulein injection. 12h
later, serum samples were obtained to assess pancreatic function the
lipase and amylase values. The animals were euthanized and lung
samples were excised. The specimens were stained with
hematoxylin-eosin (H&E), periodic acid–Schif (PAS), Mallory's
trichrome and amyloid. Additionally, oxidative DNA damage was
determined by measuring as increases in 8-hydroxy-deoxyguanosine
(8-OH-dG) adducts. The results showed that the serum activity of
lipase and amylase in AP rats were significantly reduced after the
therapy (p<0.05). We also found that the 100 mg/kg dose of CAR
significantly decreased 8-OH-dG levels. Moreover, the severe
pathological findings in the lung such as necrosis, inflammation,
congestion, fibrosis, and thickened alveolar septum were attenuated
in the AP+CAR groups when compared with AP group. Finally, the
magnitude of the protective effect on lung is certain, and CAR is an
effective therapy for lung injury caused by AP.},
	    journal   = {International Journal of Bioengineering and Life Sciences},
	  volume    = {10},
	  number    = {5},
	  year      = {2016},
	  pages     = {301 - 308},
	  ee        = {https://publications.waset.org/pdf/10004542},
	  url   	= {https://publications.waset.org/vol/113},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 113, 2016},
	}