Dong Xie and Leah Howard and Yiming Weng
An Antibacterial Dental Restorative Containing 3,4Dichlorocrotonolactone Synthesis, Formulation and Evaluation
73 - 78
2016
10
2
International Journal of Biomedical and Biological Engineering
https://publications.waset.org/pdf/10003686
https://publications.waset.org/vol/110
World Academy of Science, Engineering and Technology
The objective of this study was to synthesize and characterize 5acryloyloxy3,4dichlorocrotonolactone (a furanone derivative), use this derivative to modify a dental restorative, and study the effect of the derivative on the antibacterial activity and compressive strength of the formed restorative. In this study, a furanone derivative was synthesized, characterized, and used to formulate a dental restorative. Compressive strength (CS) and S. mutans viability were used to evaluate the mechanical strength and antibacterial activity of the formed restorative. The fabricated restorative specimens were photocured and conditioned in distilled water at 37oC for 24 h, followed by direct testing for CS orand incubating with S. mutans for 48 h for antibacterial testing. The results show that the modified dental restorative showed a significant antibacterial activity without substantially decreasing the mechanical strengths. With addition of the antibacterial derivative up to 30, the restorative kept its original CS nearly unchanged but showed a significant antibacterial activity with 68 reduction in the S. mutans viability. Furthermore, the antibacterial function of the modified restorative was not affected by human saliva. The aging study also indicates that the modified restorative may have a longlasting antibacterial function. It is concluded that this experimental antibacterial restorative may potentially be developed into a clinically attractive dental filling restorative due to its high mechanical strength and antibacterial function.
Open Science Index 110, 2016