%0 Journal Article
	%A Amr A. Fouad and  Hamed A. Alwadaani and  Iyad Jresat
	%D 2016
	%J International Journal of Animal and Veterinary Sciences
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 110, 2016
	%T Protective Effect of Thymoquinone against Nephrotoxicity Induced by Cadmium in Rats
	%U https://publications.waset.org/pdf/10003577
	%V 110
	%X The present study investigated the protective effect of
thymoquinone (TQ), against cadmium-induced kidney injury in rats.
Cadmium chloride (1.2 mg Cd/kg/day, s.c.), was given for nine
weeks. TQ treatment (40 mg/kg/day, p.o.) started on the same day of
cadmium administration and continued for nine weeks. TQ
significantly decreased serum creatinine, renal malondialdehyde and
nitric oxide, and significantly increased renal reduced glutathione in
rats received cadmium. Histopathological examination showed that
TQ markedly minimized renal tissue damage induced by cadmium.
Immunohistochemical analysis revealed that TQ markedly decreased
the cadmium-induced expression of inducible nitric oxide synthase,
tumor necrosis factor-α, cyclooxygenase-2, and caspase-3 in renal
tissue. It was concluded that TQ significantly protected against
cadmium nephrotoxicity in rats, through its antioxidant, antiinflammatory,
and antiapoptotic actions.
	%P 73 - 76