%0 Journal Article
	%A Amer A. Hasan and  Mehri Igci and  Ersin Borazan and  Rozhgar A. Khailany and  Emine Bayraktar and  Ahmet Arslan
	%D 2015
	%J International Journal of Medical and Health Sciences
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 102, 2015
	%T Down-Regulated Gene Expression of GKN1 and GKN2 as Diagnostic Markers for Gastric Cancer
	%U https://publications.waset.org/pdf/10003034
	%V 102
	%X Gastric Cancer (GC) has high morbidity and fatality
rate in various countries. It is still one of the most frequent and
deadly diseases. Gastrokine1 (GKN1) and gastrokine2 (GKN2) genes
are highly expressed in the normal stomach epithelium and play
important roles in maintaining the integrity and homeostasis of
stomach mucosal epithelial cells. In this study, 47 paired samples that
were grouped according to the types of gastric cancer and the clinical
characteristics of the patients, including gender and average of age.
They were investigated with gene expression analysis and mutation
screening by monitoring RT-PCR, SSCP and nucleotide sequencing
techniques. Both GKN1 and GKN2 genes were observed significantly
reduced found by (Wilcoxon signed rank test; p
	%P 532 - 535