@article{(Open Science Index):https://publications.waset.org/pdf/10002778,
	  title     = {Human Absorbed Dose Estimation of a New IN-111 Imaging Agent Based on Rat Data},
	  author    = {H. Yousefnia and  S. Zolghadri},
	  country	= {},
	  institution	= {},
	  abstract     = {The measurement of organ radiation exposure dose is
one of the most important steps to be taken initially, for developing a
new radiopharmaceutical. In this study, the dosimetric studies of a
novel agent for SPECT-imaging of the bone metastasis, 111In-
1,4,7,10-tetraazacyclododecane-1,4,7,10 tetraethylene phosphonic
acid (111In-DOTMP) complex, have been carried out to estimate the
dose in human organs based on the data derived from rats. The
radiolabeled complex was prepared with high radiochemical purity in
the optimal conditions. Biodistribution studies of the complex was
investigated in the male Syrian rats at selected times after injection
(2, 4, 24 and 48 h). The human absorbed dose estimation of the
complex was made based on data derived from the rats by the
radiation absorbed dose assessment resource (RADAR) method.
111In-DOTMP complex was prepared with high radiochemical purity
of >99% (ITLC). Total body effective absorbed dose for 111In-
DOTMP was 0.061 mSv/MBq. This value is comparable to the other
111In clinically used complexes. The results show that the dose with
respect to the critical organs is satisfactory within the acceptable
range for diagnostic nuclear medicine procedures. Generally, 111In-
DOTMP has interesting characteristics and can be considered as a
viable agent for SPECT-imaging of the bone metastasis in the near
future.},
	    journal   = {International Journal of Physical and Mathematical Sciences},
	  volume    = {9},
	  number    = {10},
	  year      = {2015},
	  pages     = {627 - 631},
	  ee        = {https://publications.waset.org/pdf/10002778},
	  url   	= {https://publications.waset.org/vol/106},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 106, 2015},
	}