@article{(Open Science Index):https://publications.waset.org/pdf/10001741,
	  title     = {The Toxicity of Doxorubicin with Nanotransporters},
	  author    = {I. Blazkova and  A. Moulick and  V. Milosavljevic and  P. Kopel and  M. Vaculovicova and  V. Adam and  R. Kizek},
	  country	= {},
	  institution	= {},
	  abstract     = {Doxorubicin (DOX) is an anthracycline drug used to treat many cancer diseases. Similarly to other cytostatic drugs, DOX has serious side effects; the biggest obstacle is the cardiotoxicity. With the aim of lowering the negative side effects and to target the DOX into the tumor tissue, the different nanoparticles (NPs) are studied. The aim of this work was to synthetized different NPs and conjugated them with DOX and determine the binding capacity of the NPs. For this experiment, carbon nanotubes (CNTs), graphene oxide (GO), fullerene (FUL) and liposomes (LIP) were used. The highest binding capacity was observed in GO (85%). Subsequently the toxicity of NPs and NPs-DOX conjugates was analyzed in in vivo system (chicken embryos). Some NPs (GO) can increase the toxicity of DOX, whereas other NPs (LIP, CNTs) decrease DOX toxicity.
},
	    journal   = {International Journal of Chemical and Molecular Engineering},
	  volume    = {9},
	  number    = {7},
	  year      = {2015},
	  pages     = {813 - 816},
	  ee        = {https://publications.waset.org/pdf/10001741},
	  url   	= {https://publications.waset.org/vol/103},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 103, 2015},
	}