{"title":"Object-Oriented Programming for Modeling and Simulation of Systems in Physiology","authors":"J. Fernandez de Canete","volume":100,"journal":"International Journal of Biomedical and Biological Engineering","pagesStart":343,"pagesEnd":347,"ISSN":"1307-6892","URL":"https:\/\/publications.waset.org\/pdf\/10001011","abstract":"
Object-oriented modeling is spreading in current
\r\nsimulation of physiological systems through the use of the individual
\r\ncomponents of the model and its interconnections to define the
\r\nunderlying dynamic equations. In this paper we describe the use of
\r\nboth the SIMSCAPE and MODELICA simulation environments in
\r\nthe object-oriented modeling of the closed loop cardiovascular
\r\nsystem. The performance of the controlled system was analyzed by
\r\nsimulation in light of the existing hypothesis and validation tests
\r\npreviously performed with physiological data. The described
\r\napproach represents a valuable tool in the teaching of physiology for
\r\ngraduate medical students.<\/p>\r\n","references":"[1] K. Thomaseth, \u201cMultidisciplinary modelling of biomedical systems\u201d,\r\nComput. Methods Programs Biomed, vol. 71, pp. 189-201, 2003.\r\n[2] M. Hakman, T. Groth, \u201cObject-oriented biomedical system modelling:\r\nThe rationale\u201d, Comput. Methods Programs Biomed, vol. 59, pp. 1-17,\r\n1999.\r\n[3] P. Fritzson, Introduction to Modeling and Simulation of Technical and\r\nPhysical Systems with MODELICA. Wiley-IEEE Press, 2011.\r\n[4] J. Fernandez de Canete, C. Galindo, I. Garcia-Moral, System\r\nEngineering and Automation. An interactive Educational Approach,\r\nSpringer-Verlag, 2011.\r\n[5] C.F. Rothe, J.M. Gersting, \u201cCardiovascular interactions: an interactive\r\ntutorial and mathematical model\u201d, Am. J. Physiol. Adv. Physiol. Educ.,\r\nvol. 26, pp. 98\u2013109, 2002\r\n[6] J.J. Batzel, F. Kappel, D. Schneditz, H.T. Tran, \u201cCardiovascular and\r\nRespiratory Systems: Modeling, Analysis, and Control\u201d in Frontiers in\r\nApplied Mathematics, SIAM, 2006.\r\n[7] G.M. Raymond, E. Butterworth, J.B. Bassingthwaighte, \u201cJSIM: Free\r\nsoftware package for teaching physiological modeling and research\u201d,\r\nExp. Biol., vol. 280, pp. 102-107, 2003.\r\n[8] V.I. McLoone, J.V. Ringwood, B.N. VanVliet, \u201cGraphical simulation\r\nenvironments for modeling and simulation of integrative physiology\u201d,\r\nComput. Meth. Prog. Bio., vol. 102, no. 3, pp. 295-304, 2011.\r\n[9] K.E. Brenan, S.L. Campbell, L.R. Petzold LR, Numerical solution of\r\ninitial value problems in differential algebraic equations, SIAM, 2nd\r\nedition, 2011.\r\n[10] G. Avanzolini, P. Barbini, A. Cappello, G. Cevenini, \u201cCACDS\r\nsimulation of the closed-loop cardiovascular system\u201d, Int. J. Biomed.\r\nComput., vol. 22 pp. 39-49, 1988.","publisher":"World Academy of Science, Engineering and Technology","index":"Open Science Index 100, 2015"}