%0 Journal Article
	%A H. Bouaziz and  N. Soudania and  M. Essafia and  I. Ben Amara and  A. Hakim and  K. Jamoussi and  Km. Zeghal and  N. Zeghal
	%D 2015
	%J International Journal of Environmental and Ecological Engineering
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 99, 2015
	%T Hepatotoxicity Induced by Arsenic Trioxide in Adult Mice and Their Progeny
	%U https://publications.waset.org/pdf/10000655
	%V 99
	%X In this investigation, we have evaluated the effects of
arsenic trioxide on hepatic function in pregnant and lactating Swiss
albino mice and their suckling pups. Experiments were carried out on
female mice given 175 ppm As2O3 in their drinking water from the
14th day of pregnancy until day 14 after delivery. Our results showed
a significant decrease in plasma levels of total protein and albumin,
cholesterol and triglyceride in As2O3 treated mice and their pups. The
hyperbilirubinemia and the increased plasma total alkaline
phosphatase activity suggested the presence of cholestasis.
Transaminase activities as well as lactate deshydrogenase activity in
plasma, known as biomarkers of hepatocellular injury, were elevated
indicating hepatic cells’ damage after treatment with As2O3.
Exposure to arsenic led to an increase of liver thiobarbituric acid
reactive substances level along with a concomitant decrease in the
activities of superoxide dismutase, catalase and glutathione
peroxidase and in glutathione.

	%P 250 - 255