Commenced in January 2007
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Edition: International
Paper Count: 1

poliovirus Related Publications

1 Features of the Immune Response in Mice were Immunized with Polio Vaccine in Combination with Chitosan Preparations as Adjuvants

Authors: Nelly К. Akhmatova, Оlga V. Lebedinskaya, Еlena А. Lebedinskaya, Elvin А. Akhmatov, Аnatoliy P. Godovalov, Stanislav G. Markushin, Lidiya A. Geiderova, Vera M. Axenova

Abstract:

The study of cytokine expression in mice under the influence of inactivated poliovirus and Imovaks polio vaccine in combination with derivatives of chitosan shows various kinds of processes. There is a significant increase in IL-12 in the serum of immunized animals, which should stimulate the production of IFN-γ NK-cells and T-cells and polarize the immune response to Th1 type. Thus, the derivatives of chitosan can promote cell component of the immune response, providing a full antiviral immunity.

Keywords: chitosan, poliovirus, cytokine expression, antiviral immunity

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