Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 1

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1 In vivo Evaluation of the Anti-Inflammatory, Analgesic Activities of Crataegus Sinaica Methanol Extract

Authors: Rehab F. Abdel-Rahman, A. H. El-Desoky, Gihan F. Asaad

Abstract:

Objective: The research was designed to study the anti-inflammatory and analgesic effect of Crataegus sinaica methanol extract Methods: The anti-inflammatory were measured by edema rate and inhibition rate using plethysmometer and by determinig PGE2, TNF-ɑ and MPO levels in paw exudate. Both central and peripheral analgesic effect were examined using Writhing test and hot plate test Key Findings: The methanolic extract showed a significant anti-inflammatory effect by decreasing paw edema induced by carrageenan; also results showed that anti-inflammatory effect increased by increasing the dose. All dose levels of the extract showed significant reduction in Prostaglandin E2, Tumor necrosis factor-ɑ, and Meyloperoxidase levels. Crataegus sinaica methanol extract showed both peripheral and central analgesic effect. Conclusion: The C. sinaica methanolic extract can be considered a promising anti-inflammatory and analgesic product.

Keywords: Pain, Analgesia, prostaglandins, edema, Crataegus sinaica, hot plate

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