@article{(Open Science Index):https://publications.waset.org/pdf/9999377,
	  title     = {Comparing Spontaneous Hydrolysis Rates of Activated Models of DNA and RNA},
	  author    = {Mohamed S. Sasi and  Adel M. Mlitan and  Abdulfattah M. Alkherraz},
	  country	= {},
	  institution	= {},
	  abstract     = {This research project aims to investigate difference in
relative rates concerning phosphoryl transfer relevant to biological
catalysis of DNA and RNA in the pH-independent reactions.
Activated Models of DNA and RNA for alkyl-aryl phosphate diesters
(with 4-nitrophenyl as a good leaving group) have successfully been
prepared to gather kinetic parameters. Eyring plots for the pH–
independent hydrolysis of 1 and 2 were established at different
temperatures in the range 100–160 °C. These measurements have
been used to provide a better estimate for the difference in relative
rates between the reactivity of DNA and RNA cleavage. Eyring plot
gave an extrapolated rate of kH2O = 1 × 10-10 s -1 for 1 (RNA model)
and 2 (DNA model) at 25°C. Comparing the reactivity of RNA
model and DNA model shows that the difference in relative rates in
the pH-independent reactions is surprisingly very similar at 25°. This
allows us to obtain chemical insights into how biological catalysts
such as enzymes may have evolved to perform their current
functions.
},
	    journal   = {International Journal of Agricultural and Biosystems Engineering},
	  volume    = {8},
	  number    = {9},
	  year      = {2014},
	  pages     = {1010 - 1012},
	  ee        = {https://publications.waset.org/pdf/9999377},
	  url   	= {https://publications.waset.org/vol/93},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 93, 2014},
	}