{"title":"Surfactant-Free O\/W-Emulsion as Drug Delivery System","authors":"M. Kumpugdee-Vollrath, J.-P. Krause, S. B\u00fcrk","volume":93,"journal":"International Journal of Pharmacological and Pharmaceutical Sciences","pagesStart":574,"pagesEnd":578,"ISSN":"1307-6892","URL":"https:\/\/publications.waset.org\/pdf\/9999359","abstract":"
Most of the drugs used for pharmaceutical purposes
\r\nare poorly water-soluble drugs. About 40% of all newly discovered
\r\ndrugs are lipophilic and the numbers of lipophilic drugs seem to
\r\nincrease more and more. Drug delivery systems such as
\r\nnanoparticles, micelles or liposomes are applied to improve their
\r\nsolubility and thus their bioavailability. Besides various techniques of
\r\nsolubilization, oil-in-water emulsions are often used to incorporate
\r\nlipophilic drugs into the oil phase. To stabilize emulsions surface
\r\nactive substances (surfactants) are generally used. An alternative
\r\nmethod to avoid the application of surfactants was of great interest.
\r\nOne possibility is to develop O\/W-emulsion without any addition of
\r\nsurface active agents or the so called “surfactant-free emulsion or
\r\nSFE”. The aim of this study was to develop and characterize SFE as a
\r\ndrug carrier by varying the production conditions. Lidocaine base
\r\nwas used as a model drug. The injection method was developed.
\r\nEffects of ultrasound as well as of temperature on the properties of
\r\nthe emulsion were studied. Particle sizes and release were
\r\ndetermined. The long-term stability up to 30 days was performed.
\r\nThe results showed that the surfactant-free O\/W emulsions with
\r\npharmaceutical oil as drug carrier can be produced.<\/p>\r\n","references":"[1] V. S. Monika, A. Nawazish \"A brief review on solubility enhancement\r\nof poorly water soluble drugs\u201d, International Journal of Natural Product\r\nScience, Spl Issue 1, p. 6, 2012.\r\n[2] C. Buzea, I. I. P. Blandino, K. Robbi, \"Nanomaterials and nanoparticles:\r\nSources and toxicity\", Biointerphases, vol. 2, issue 4, pp MR17 -\r\nMR172, 2007.\r\n[3] T. Sakai, \"Surfactant-free emulsions\", Current Opinion in Colloid &\r\nInterface Science, Volume 13, Issue 4, August, pp. 228-235, 2008.\r\n[4] K. Kamogawa, H. Akatsuka, M. Matsumoto, S. Yokoyama, T. Sakai, H.\r\nSakai, M. Abe, \"Surfactant-free O\/W emulsion formation of oleic acid\r\nand its esters with ultrasonic dispersion\", Colloids and Surfaces A:\r\nPhysicochemical and Engineering Aspects, Volume 180, Issues 1\u20132, 15\r\nMay, pp. 41-53, 2001.\r\n[5] C. Liang, Q. Liu, Z. Xu, \"Surfactant-free switchable emulsions using\r\nCO2-responsive particles\", ACS Appl Mater Interfaces, May 14, 6(9),\r\npp. 6898-904, 2014.\r\n[6] Y. Wu, Q. Li, F. Deng, X. Liang, H. Liu, \"Solvent effect on \u03b6 potential\r\nat an aqueous\/oil interface in surfactant-free emulsion\", Langmuir, Mar\r\n4, 30(8), pp. 1926-31, 2014.","publisher":"World Academy of Science, Engineering and Technology","index":"Open Science Index 93, 2014"}